Search results for "RedOx metabolism"
showing 4 items of 4 documents
Homoarginine Levels are Regulated by L-Arginine: Glycine Amidinotransferase and Affect Stroke Outcome: Results from Human and Murine Studies
2013
Background— Endogenous arginine homologues, including homoarginine, have been identified as novel biomarkers for cardiovascular disease and outcomes. Our studies of human cohorts and a confirmatory murine model associated the arginine homologue homoarginine and its metabolism with stroke pathology and outcome. Methods and Results— Increasing homoarginine levels were independently associated with a reduction in all-cause mortality in patients with ischemic stroke (7.4 years of follow-up; hazard ratio for 1-SD homoarginine, 0.79 [95% confidence interval, 0.64–0.96]; P =0.019; n=389). Homoarginine was also independently associated with the National Institutes of Health Stroke Scale+age score …
Contribution to the research of microbial and RedOx bio-indicators for the early characterisation of wood diseases in grapevines
2022
Grapevine trunk diseases, linked to pathogenic fungi whose mechanism of action is still poorly characterised, are responsible for grapevine decline in vineyards throughout the world, causing significant losses in productivity and yield in the wine sector. Given the current lack of effective solutions to stop the establishment of the disease and the development of symptoms, which are irreversible but often late in relation to the pathogenic infection, early diagnosis of these diseases is essential. Considering the grapevine holobiont, i.e. the grapevine and the microbiota interacting with, we hypothesise that early bio-indicators of diseases would make it possible to identify a disturbance i…
Autophagy
2012
Klionsky, Daniel J. et al.
Development of the first marmoset-specific DNA microarray (EUMAMA): a new genetic tool for large-scale expression profiling in a non-human primate
2007
Abstract Background The common marmoset monkey (Callithrix jacchus), a small non-endangered New World primate native to eastern Brazil, is becoming increasingly used as a non-human primate model in biomedical research, drug development and safety assessment. In contrast to the growing interest for the marmoset as an animal model, the molecular tools for genetic analysis are extremely limited. Results Here we report the development of the first marmoset-specific oligonucleotide microarray (EUMAMA) containing probe sets targeting 1541 different marmoset transcripts expressed in hippocampus. These 1541 transcripts represent a wide variety of different functional gene classes. Hybridisation of …